What is MACS?

MACS (Magnetic Activated Cell Sorting) or Annexin V Columns is a technique to select spermatozoids which do not show signs of apoptosis (programmed cell death before the sperm are able to fertilise), in order to use them in assisted reproduction.

It has been demonstrated that the sperm cells of patients with an elevated sperm DNA fragmentation index have cell damage. MACS is a complementary sperm preparation technique designed to select the most viable sperm for fertilisation of the eggs in cases involving elevated sperm DNA fragmentation.

MACS - URE Centro Gutenberg

When is MACS indicated?


Patients with an elevated sperm DNA fragmentation index


Patients with recurrent miscarriage


Patients who have not achieved a pregnancy after two or more cycles


Males of advanced age

The MACS Procedure

MACS is a simple technique which only requires a sperm sample. The sample will be processed in the laboratory to select spermatozoids using Annexin V Columns. The healthiest sperm will be retrieved for fertilisation with the eggs.

More info

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