{"id":39557,"date":"2025-06-23T12:57:39","date_gmt":"2025-06-23T10:57:39","guid":{"rendered":"https:\/\/urecentrogutenberg.es\/unexplained-infertility-and-the-treatments-that-are-used-to-tackle-it\/"},"modified":"2025-06-23T12:57:39","modified_gmt":"2025-06-23T10:57:39","slug":"unexplained-infertility","status":"publish","type":"post","link":"https:\/\/urecentrogutenberg.es\/en\/unexplained-infertility\/","title":{"rendered":"Unexplained infertility and the treatments that are used to tackle it"},"content":{"rendered":"<p>The inability to conceive naturally is a common problem in our society. In fact, recent studies indicate that\u00a0<strong>infertility is currently affecting between 18% and 20% of the world population<\/strong>. But\u2026 what is the cause of these issues that are preventing natural conception from occurring? What\u2019s true is that there are many, very different reasons: 30% of cases can be attributed to\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/female-infertility-conditions-and-diseases-that-can-cause-it\/\" target=\"_blank\" rel=\"noopener\">female factors<\/a>, another 30% to\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/male-infertility-common-illnesses-that-can-cause-it\/\" target=\"_blank\" rel=\"noopener\">male-related factors<\/a>\u00a0and 20% of cases are found to be a combination of both male and female factors. And what about that remaining 20%? This is where what we refer to as unexplained causes of infertility come into the picture.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Tabla de contenidos<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #3f3f3f;color:#3f3f3f\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #3f3f3f;color:#3f3f3f\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/urecentrogutenberg.es\/en\/unexplained-infertility\/#What_is_unexplained_infertility\" >What is unexplained infertility?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/urecentrogutenberg.es\/en\/unexplained-infertility\/#What_tests_are_performed_on_females_in_order_to_detect_fertility_issues\" >What tests are performed on females in order to detect fertility issues?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/urecentrogutenberg.es\/en\/unexplained-infertility\/#What_tests_are_performed_on_males_in_order_to_detect_fertility_issues\" >What tests are performed on males in order to detect fertility issues?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/urecentrogutenberg.es\/en\/unexplained-infertility\/#Sources_of_infertility_without_a_clear_cause\" >Sources of infertility without a clear cause<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/urecentrogutenberg.es\/en\/unexplained-infertility\/#What_treatment_options_exist_for_unexplained_infertility\" >What treatment options exist for unexplained infertility?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/urecentrogutenberg.es\/en\/unexplained-infertility\/#What_can_be_done_to_improve_treatment_conditions_during_a_cycle\" >What can be done to improve treatment conditions during a cycle?<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_unexplained_infertility\"><\/span>What is unexplained infertility?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\u201cIf nothing is wrong with us, why can\u2019t we get pregnant?\u201d This is usually the very first question that females and couples with this problem ask each other. What generally happens is that they go to see a specialist and undergo all of the diagnostic testing,\u00a0<strong>and when they return to the doctor to discuss their results \u2026 everything is normal<\/strong>. So now what? When this occurs we are dealing with a case of unexplained infertility.<\/p>\n<p>The good news is that\u00a0<strong>the prognosis is good in the majority of cases<\/strong>\u00a0even though the couple will require help through assisted reproduction treatment. In patients with unexplained infertility, the prognosis will be highly dependent on their ages and the number of years they\u2019ve been trying to conceive.<\/p>\n<p>In fact, we need to keep in mind that this definition will be different for patients over the age of 38-40, as the determining factor in these cases is\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/ovarian-reserve-and-assisted-reproduction\/\" target=\"_blank\" rel=\"noopener\"><strong>a low ovarian reserve<\/strong><\/a>, which sometimes goes hand in hand with poor egg quality. This means that in these cases we\u2019re no longer talking about unexplained infertility seeing as the couple\u2019s inability to conceive can be associated with specific causes.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_tests_are_performed_on_females_in_order_to_detect_fertility_issues\"><\/span>What tests are performed on females in order to detect fertility issues?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>As we were saying, before we are able to diagnose a couple with unexplained infertility there is\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/basic-fertility-study-what-tests-are-needed\/\" target=\"_blank\" rel=\"noopener\"><strong>testing which must be carried out on the female<\/strong><\/a>\u00a0and on her partner. For females, we will perform a detailed interview regarding their medical history and also perform a physical, gynaecological exam including a transvaginal ultrasound in order to evaluate the uterus and the ovaries.<\/p>\n<p>There is also complementary testing that we may request in order to study ovarian function (baseline hormones including FSH, LH, estradiol\u2026,\u00a0<strong>anti-m\u00fcllerian hormone<\/strong>), a hysterosalpingogram (to study the permeability of the fallopian tubes), and a\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/diagnostic-hysteroscopy-in-assisted-reproduction\/\" target=\"_blank\" rel=\"noopener\"><strong>hysteroscopy<\/strong><\/a>\u00a0(to evaluate the uterine cavity), for patients who have already had unsuccessful attempts in previous cycles.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_tests_are_performed_on_males_in_order_to_detect_fertility_issues\"><\/span>What tests are performed on males in order to detect fertility issues?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>For males, in addition to a rigorous interview regarding their medical history and a physical exam, if necessary, the most common diagnostic tool is\u00a0<strong>to run a sperm analysis<\/strong>, a study which will help us to pinpoint a possible male-related factor.<\/p>\n<p>Here you\u2019ll find more information about\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/what-is-study-male-fertility\/\" target=\"_blank\" rel=\"noopener\"><strong>what fertility testing is like for males<\/strong><\/a>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Sources_of_infertility_without_a_clear_cause\"><\/span>Sources of infertility without a clear cause<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Despite all the tests and studies, the truth is that it is sometimes complicated to determine the reasons why a couple hasn\u2019t been able to conceive. Fortunately, in recent years with advances in reproductive medicine and generally after undergoing in vitro fertilisation,\u00a0<strong>some of what could be the causes of unexplained infertility have been detected<\/strong>.<\/p>\n<p>Among these causes we have found, first and foremost,\u00a0<strong>chromosome abnormalities in the eggs<\/strong>: the older the female, the higher the likelihood of finding eggs with poor quality.<\/p>\n<p><strong>Genetic abnormalities in spermatozoids<\/strong>\u00a0have also been identified. Abnormalities in the genetic make-up of sperm could lead to fertilisation failure or poor embryo development.<\/p>\n<p>Finally, we must also talk about\u00a0<strong>embryo abnormalities<\/strong>. When we are dealing with\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Embryo\" target=\"_blank\" rel=\"noopener\">embryos<\/a>\u00a0whose cells are fragmented and\/or asymmetrical, or embryos with several nuclei\u2026 we know that these embryos are more likely to stop developing and to cause the treatment to result in implantation failure or miscarriage.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_treatment_options_exist_for_unexplained_infertility\"><\/span>What treatment options exist for unexplained infertility?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for these types of patients must be based on the\u00a0<strong>individual characteristics of each person and each couple<\/strong>. This is why a special focus must be placed on the patients\u2019 ages, as well as on a good physical and emotional preparation for treatment in order to help us confront the process that much more easily.<\/p>\n<p>Treatment, in some cases, will also serve the purpose of allowing us to diagnose any\u00a0<strong>underlying causes responsible for preventing natural conception<\/strong>, such as poor egg or poor embryo quality, which may in turn lead us to more complex procedures.<\/p>\n<p>It is important to keep in mind that deciding the best way to proceed will always be left to the discretion of the specialist, while taking the couple\u2019s opinions into consideration. Normally treatment is carried out in stages, starting with the most simple procedures first, such as\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/artificial-insemination-frequently-asked-questions-about-this-assisted-reproduction-treatment\/\" target=\"_blank\" rel=\"noopener\"><strong>artificial insemination<\/strong><\/a>; \u00a0if simple treatments are not successful then the patient will progress to more complex techniques such as\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/in-vitro-fertilisation\/\" target=\"_blank\" rel=\"noopener\"><strong>in vitro fertilisation<\/strong><\/a>\u00a0or, if necessary,\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/egg-donation\/\" target=\"_blank\" rel=\"noopener\"><strong>egg<\/strong><strong>\u00a0donation<\/strong>.<\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_can_be_done_to_improve_treatment_conditions_during_a_cycle\"><\/span>What can be done to improve treatment conditions during a cycle?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In addition to everything we\u2019ve discussed up until this point, we would also like to share some\u00a0<strong>tips that might help you while undergoing assisted reproduction treatment<\/strong>. What you\u2019ll read here is simple and straightforward advice, but these tips will have a bigger impact than you would think when it comes to trying to conceive with the help of fertility treatment.<\/p>\n<p>Tip number one is to eat a\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/foods-that-improve-female-fertility-truths-and-misconceptions\/\" target=\"_blank\" rel=\"noopener\"><strong>healthy and balanced diet<\/strong><\/a>\u00a0with a special focus on fruits and vegetables as they are rich in vitamins, minerals and antioxidants.<\/p>\n<p>On a related note, it\u2019s important to get physical activity to help maintain a good level of general health and to reduce the high stress and anxiety levels that often appear when trying to conceive. In addition,\u00a0<strong>being overweight is an obstacle when it comes to trying to conceive<\/strong>\u00a0, so regular exercise will help with this as well.<\/p>\n<p>Finally, it is also essential to eliminate or reduce, to the extent possible, the intake of substances such as tobacco, alcohol and caffeine, as their consumption is considered to be one of the\u00a0<strong>most detrimental habits to our fertility<\/strong>.<\/p>\n<p>We hope we\u2019ve been able to help you better understand what unexplained infertility is, what the possible causes are, the tests we run in order to rule out different pathologies and also what you can do to improve your fertility. As always,\u00a0<strong>at URE Centro Gutenberg we\u2019re here to help\u00a0<\/strong>answer any questions you may have and to assist you with anything else you may need.<\/p>\n<p>You can request an appointment with our assisted reproduction specialists\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/contact\/\" target=\"_blank\" rel=\"noopener\"><strong>by clicking here<\/strong><\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The inability to conceive naturally is a common problem in our society. In fact, recent studies indicate that\u00a0infertility is currently affecting between 18% and 20% of the world population. But\u2026 what is the cause of these issues that are preventing natural conception from occurring? What\u2019s true is that there are many, very different reasons: 30% [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":35155,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[497,501],"tags":[552,512,529,543,550,531,518,508,502,513,503,620,619,506,515],"class_list":["post-39557","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fertility-problems","category-lifestyle-and-fertility-en","tag-artificial-insemination-malaga","tag-assisted-reproduction-clinic-in-malaga","tag-causes-of-infertility","tag-centro-gutenberg-en","tag-centro-gutenberg-malaga-en","tag-fertility","tag-fertility-clinic","tag-fertility-clinic-in-malaga","tag-fertility-treatments","tag-fertility-treatments-in-malaga","tag-in-vitro-fertilisation","tag-infertility-for-no-apparent-reason","tag-infertility-of-unknown-origin","tag-pregnancy","tag-reproductive-treatments"],"_links":{"self":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/comments?post=39557"}],"version-history":[{"count":3,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39557\/revisions"}],"predecessor-version":[{"id":39734,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39557\/revisions\/39734"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/media\/35155"}],"wp:attachment":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/media?parent=39557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/categories?post=39557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/tags?post=39557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}