{"id":39541,"date":"2025-06-23T12:58:03","date_gmt":"2025-06-23T10:58:03","guid":{"rendered":"https:\/\/urecentrogutenberg.es\/duostim-or-double-ovarian-stimulation-for-patients-with-diminished-ovarian-reserve\/"},"modified":"2025-06-23T12:58:03","modified_gmt":"2025-06-23T10:58:03","slug":"duostim-double-ovarian-stimulation","status":"publish","type":"post","link":"https:\/\/urecentrogutenberg.es\/en\/duostim-double-ovarian-stimulation\/","title":{"rendered":"DUOSTIM or double-ovarian-stimulation for patients with diminished ovarian reserve."},"content":{"rendered":"<p>Is it possible to become a mom if I have a diminished ovarian reserve? Our answer is yes, conceiving and becoming a mother is possible even if you have a low ovarian reserve, though sometimes we need help from\u00a0<strong>assisted reproduction techniques<\/strong>\u00a0to achieve a pregnancy.<\/p>\n<p>One of these assisted reproduction techniques is called\u00a0<strong>DUOSTIM, or a double ovarian stimulation<\/strong>, which we\u2019ll discuss here.<\/p>\n<p>&nbsp;<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Tabla de contenidos<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #3f3f3f;color:#3f3f3f\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #3f3f3f;color:#3f3f3f\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/urecentrogutenberg.es\/en\/duostim-double-ovarian-stimulation\/#What_is_DUOSTIM_A_double_ovarian_stimulation\" >What is DUOSTIM? A double ovarian stimulation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/urecentrogutenberg.es\/en\/duostim-double-ovarian-stimulation\/#When_is_a_DUOSTIM_protocol_recommended\" >When is a DUOSTIM protocol recommended?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/urecentrogutenberg.es\/en\/duostim-double-ovarian-stimulation\/#Advantages_of_DUOSTIM_or_double_ovarian_stimulation\" >Advantages of DUOSTIM, or double ovarian stimulation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/urecentrogutenberg.es\/en\/duostim-double-ovarian-stimulation\/#Disadvantages_of_DUOSTIM_or_double_ovarian_stimulation\" >Disadvantages of DUOSTIM, or double ovarian stimulation<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_DUOSTIM_A_double_ovarian_stimulation\"><\/span>What is DUOSTIM? A double ovarian stimulation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&nbsp;<\/p>\n<p>It is an\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/ovarian-stimulation-in-assisted-reproduction-we-answer-your-most-frequently-asked-questions\/\" target=\"_blank\" rel=\"noopener\"><strong>ovarian stimulation<\/strong><\/a>\u00a0strategy meant to achieve a greater number of eggs and, as a result, a greater number of embryos, in a shorter period of time than usual. This process is carried out with the goal of improving cumulative live-birth rates.<\/p>\n<p>It involves performing\u00a0<strong>two ovarian stimulations and two\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/the-egg-retrieval-process-step-by-step\/\" target=\"_blank\" rel=\"noopener\">egg retrievals<\/a>\u00a0in the same ovarian cycle<\/strong>. The first egg retrieval procedure is carried out on day 10, 11 or 12 of the hormone administration which was started on cycle day 1, 2 or 3; the second egg retrieval is performed on day 12, 13 or 14 of the next round of hormone administration.<\/p>\n<p>After the first egg retrieval, we normally wait about three to five days before starting the second ovarian stimulation with hormones and then performing the second egg retrieval about 12 to 14 days later.<\/p>\n<p>So,\u00a0<strong>how long does this double ovarian stimulation take?<\/strong>\u00a0Both egg collection procedures are carried out over a period of about 30 to 40 days. To compare: if two rounds of traditional ovarian stimulation had been carried out, we would have been looking at a longer timeframe as each round of hormone administration would have to start at the beginning of two consecutive menstrual cycles.<\/p>\n<p>This process is based on the belief that two or three waves of egg production can occur during a single\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/what-are-the-main-phases-of-the-menstrual-cycle\/\" target=\"_blank\" rel=\"noopener\"><strong>ovarian cycle<\/strong><\/a>:<\/p>\n<ol>\n<li>At the beginning of the period, which is the first wave that the standard protocol makes use of.<\/li>\n<li>Around the time of\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/ovulation-why-its-important-to-know-when-it-takes-place-in-assisted-reproduction\/\" target=\"_blank\" rel=\"noopener\"><strong>ovulation<\/strong><\/a>.<\/li>\n<li>During the luteal phase, or post-ovulation.<\/li>\n<\/ol>\n<p><strong>The luteal phase\u00a0is when the recruitment of additional eggs begins during the second round of stimulation<\/strong>\u00a0(the first egg collection would be viewed as ovulation). It has been shown that the maturity and chromosome makeup of the eggs collected in this phase are similar to the quality of the eggs recruited in the first egg retrieval.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"When_is_a_DUOSTIM_protocol_recommended\"><\/span>When is a DUOSTIM protocol recommended?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The DUOSTIM protocol is recommended in the following cases:<\/p>\n<ul>\n<li>Females with\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/ovarian-reserve-and-assisted-reproduction\/\" target=\"_blank\" rel=\"noopener\"><strong>diminished ovarian reserve<\/strong><\/a>, confirmed by ultrasound and\/or a low<strong>\u00a0anti-m\u00fcllerian hormone<\/strong>\u00a0value, who want to maximise the number of eggs available.<\/li>\n<li><a href=\"https:\/\/urecentrogutenberg.es\/en\/pregnancy-after-the-age-of-40-is-possible\/\" target=\"_blank\" rel=\"noopener\"><strong>Females of advanced maternal age<\/strong><\/a>\u00a0who wish to carry out\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/pre-implantation-genetic-diagnosis-spain\/\" target=\"_blank\" rel=\"noopener\"><strong>pre-implantation genetic testing<\/strong><\/a>\u00a0and want to maximise the number of embryos available for screening.<\/li>\n<li>Females who have been diagnosed with cancer and who wish to urgently\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/preservation-of-fertility\/\" target=\"_blank\" rel=\"noopener\"><strong>preserve their fertility<\/strong><\/a>\u00a0before undergoing radiotherapy or chemotherapy.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Advantages_of_DUOSTIM_or_double_ovarian_stimulation\"><\/span>Advantages of DUOSTIM, or double ovarian stimulation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>A greater number of eggs viable for fertilisation are obtained<\/strong>\u00a0(i.e.,\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/eggs-classifications-how-we-classify-eggs-in-in-vitro-fertilisation\/\" target=\"_blank\" rel=\"noopener\">mature eggs,<\/a>\u00a0also known as metaphase II), in a shorter period of time. It\u2019s an option to be considered when a patient wishes to carry out pre-implantation genetic testing as it increases the number of eggs available to work with and, as a result, increases the number of embryos available for the embryo biopsy.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Disadvantages_of_DUOSTIM_or_double_ovarian_stimulation\"><\/span>Disadvantages of DUOSTIM, or double ovarian stimulation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>Two egg collection procedures and the administration of sedation twice in a short period of time is a relative disadvantage: this is owing to the fact that sometimes higher doses of hormones are used during the second round of stimulation, and other times patients need more days of stimulation than they needed in the first round before they\u2019re ready for the second egg collection.<\/li>\n<li>The financial cost is higher.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Have we answered all your questions? Do you still have doubts regarding a double ovarian stimulation?<\/p>\n<p>If you\u2019re considering starting fertility treatment, or are simply interested in receiving information, you can\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/contact\/\" target=\"_blank\" rel=\"noopener\"><strong>request an appointment for an initial assessment<\/strong><\/a>\u00a0of your case. This first appointment is completely cost-free and\u00a0<strong>you can visit us in person or<\/strong>\u00a0connect virtually and speak with us\u00a0<strong>from the comfort of your home<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Is it possible to become a mom if I have a diminished ovarian reserve? Our answer is yes, conceiving and becoming a mother is possible even if you have a low ovarian reserve, though sometimes we need help from\u00a0assisted reproduction techniques\u00a0to achieve a pregnancy. One of these assisted reproduction techniques is called\u00a0DUOSTIM, or a double [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":37756,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[499,500,501],"tags":[615,528,612,614,613],"class_list":["post-39541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assisted-reproduction-treatments-and-techniques","category-laboratory-stuff","category-lifestyle-and-fertility-en","tag-2-oocytes-in-puncture","tag-assisted-reproduction","tag-assisted-reproduction-centre","tag-double-ovarian-stimulation","tag-duostim-en"],"_links":{"self":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/comments?post=39541"}],"version-history":[{"count":3,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39541\/revisions"}],"predecessor-version":[{"id":39722,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39541\/revisions\/39722"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/media\/37756"}],"wp:attachment":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/media?parent=39541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/categories?post=39541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/tags?post=39541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}