{"id":39523,"date":"2025-06-23T12:58:09","date_gmt":"2025-06-23T10:58:09","guid":{"rendered":"https:\/\/urecentrogutenberg.es\/recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution\/"},"modified":"2025-09-29T15:34:16","modified_gmt":"2025-09-29T13:34:16","slug":"recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution","status":"publish","type":"post","link":"https:\/\/urecentrogutenberg.es\/en\/recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution\/","title":{"rendered":"Recurrent embryo implantation failure in assisted reproduction treatment: Is there a solution?"},"content":{"rendered":"<p><strong>Human reproduction is a very complex process<\/strong>: it involves several stages, all of which need to go as planned, but that sometimes don\u2019t turn out as we had hoped.<\/p>\n<p>An example? A couple undergoing assisted reproduction treatment, specifically\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/in-vitro-fertilisation\/\" target=\"_blank\" rel=\"noopener\">in Vitro Fertilisation<\/a>, transfers very good quality embryos to an endometrium which appears to be normal, but they don\u2019t achieve a pregnancy. When this situation repeats itself over the course of at least two cycles we can start to talk about embryo implantation failure.<\/p>\n<p><strong>Is this the first time you\u2019ve heard of implantation failure?<\/strong>\u00a0<strong>Don\u2019t worry:<\/strong>\u00a0in this article we\u2019ll thoroughly explain to you what embryo implantation is\u00a0and why, on occasion, we encounter this problem and what some possible solutions are.<\/p>\n<p>&nbsp;<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Tabla de contenidos<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #3f3f3f;color:#3f3f3f\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #3f3f3f;color:#3f3f3f\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/urecentrogutenberg.es\/en\/recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution\/#What_is_embryo_implantation\" >What is embryo implantation?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/urecentrogutenberg.es\/en\/recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution\/#What_makes_embryo_implantation_possible\" >What makes embryo implantation possible?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/urecentrogutenberg.es\/en\/recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution\/#When_and_how_embryo_implantation_occurs\" >When and how embryo implantation occurs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/urecentrogutenberg.es\/en\/recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution\/#When_embryo_implantation_failure_occurs\" >When embryo implantation failure occurs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/urecentrogutenberg.es\/en\/recurrent-embryo-implantation-failure-in-assisted-reproduction-treatment-is-there-a-solution\/#What_to_do_to_achieve_a_pregnancy_in_cases_of_embryo_implantation_failure\" >What to do to achieve a pregnancy in cases of embryo implantation failure<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_embryo_implantation\"><\/span>What is embryo implantation?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>Embryo implantation is a molecular-biological process through which an embryo attaches to and invades the endometrium<\/strong>, or the tissue that lines the uterine cavity in women.<\/p>\n<p>Once implantation has taken place,\u00a0the endometrium is where the embryo will develop during the nine months of pregnancy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_makes_embryo_implantation_possible\"><\/span>What makes embryo implantation possible?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Several factors are necessary\u00a0in order for embryo implantation to take place and so that implantation failure doesn\u2019t occur.\u00a0<strong>Firstly, we need a good quality embryo that has developed well.<\/strong>\u00a0Additionally, it<strong>\u00a0is important that the endometrium has grown and matured properly<\/strong>. Finally, the embryo and endometrium must correctly coordinate and communicate with each other.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"When_and_how_embryo_implantation_occurs\"><\/span>When and how embryo implantation occurs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>Once an egg has been fertilised in the Fallopian tube, the early embryo begins the process of cell division and is transported by the tube toward the uterine cavity where it will arrive on the third or fourth day of development.<\/strong><\/p>\n<p>Then implantation starts taking place around the sixth day of embryo development and ends on day thirteen approximately. The exact moment at which this process should or can begin is known as the \u201cimplantation window\u201d, and can range from day two to day seven post-ovulation.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"When_embryo_implantation_failure_occurs\"><\/span>When embryo implantation failure occurs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>As we said at the beginning of this article, we can start to talk about implantation failure once a patient has undergone at least two assisted reproduction treatment cycles,\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/embryo-classification-by-quality-for-in-vitro-fertilisation-treatment\/\" target=\"_blank\" rel=\"noopener\">\u2011with good quality embryos<\/a>\u00a0and a normal endometrium\u2011, if a pregnancy has not been achieved.<\/p>\n<p>The causes of implantation failure can be attributed to the uterus or to the embryo. This means that there could be a problem which is preventing the embryo from properly continuing its development, or a uterine factor which is stopping implantation from taking place.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_to_do_to_achieve_a_pregnancy_in_cases_of_embryo_implantation_failure\"><\/span>What to do to achieve a pregnancy in cases of embryo implantation failure<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Patients with embryo implantation failure generally present complex cases, meaning it is always advisable to re-evaluate their situation and diagnosis to look for an explanation as to why their treatments haven\u2019t been successful, or something that may have been overlooked during the initial assessment.<\/p>\n<p>To reassess a patient\u2019s case, the medical team must review potential abnormalities regarding uterine anatomy such as\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/myomas-and-their-implications-on-female-infertility\/\" target=\"_blank\" rel=\"noopener\">submucosal fibroids<\/a>,\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/what-are-endometrial-polyps-and-their-relationship-with-infertility\/\" target=\"_blank\" rel=\"noopener\">endometrial polyps<\/a>, adhesions, etc.\u00a0<strong>The best way to evaluate the anatomy of the uterus is by performing a<a href=\"https:\/\/urecentrogutenberg.es\/en\/diagnostic-hysteroscopy-in-assisted-reproduction\/\" target=\"_blank\" rel=\"noopener\">\u00a0diagnostic hysteroscopy<\/a>,<\/strong>\u00a0a procedure during which issues are generally encountered in up to ten percent of cases.<\/p>\n<p>In terms of the female, certain factors must be ruled out such as thrombophilia, endocrine, metabolic and immune issues, as these types of problems could lead to embryo implantation failure.\u00a0<strong>You must keep in mind that it\u00a0is possible to achieve a pregnancy if given the proper treatment.<\/strong><\/p>\n<p>With regards to causes that affect the embryos, it is advisable to look into potential abnormalities on the chromosomes\u00a0of both the male and female through a karyotyping analysis. More complex abnormalities in males can also be studied through sperm samples, such as the sperm FISH analysis\u00a0and the sperm DNA fragmentation test\u00a0performed on the spermatozoids.<\/p>\n<p>There are times, however, when it is not possible to find a reason that explains why embryo implantation is failing to take place. In these instances, the way patient cases are handled or the recommendations given will depend upon each clinic\u2019s experience as well as the couple\u2019s particular case.<\/p>\n<p>When a cause for implantation failure is detected,\u00a0the treatment given will depend on the patient\u2019s diagnosis.\u00a0<strong>This means that the doctor will specifically treat the problem that has been identified and the patients will be advised to undergo a new cycle of in Vitro Fertilisation.<\/strong><\/p>\n<p>Embryo implantation failure affects between ten and fifteen percent of couples undergoing in Vitro Fertilisation treatment. However,\u00a0<strong>you need to keep in mind that by using diagnostic tools and current therapies it is possible to achieve a viable pregnancy<\/strong>\u00a0that develops as expected in over ninety percent of couples who undergo treatment at assisted reproduction clinics.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-3826 size-large\" src=\"https:\/\/fertilityclinicspain.com\/wp-content\/uploads\/2023\/02\/failure-in-assisted-reproduction-treatment-1024x576.jpg\" sizes=\"(max-width: 1024px) 100vw, 1024px\" srcset=\"https:\/\/fertilityclinicspain.com\/wp-content\/uploads\/2023\/02\/failure-in-assisted-reproduction-treatment-1024x576.jpg 1024w, https:\/\/fertilityclinicspain.com\/wp-content\/uploads\/2023\/02\/failure-in-assisted-reproduction-treatment-300x169.jpg 300w, https:\/\/fertilityclinicspain.com\/wp-content\/uploads\/2023\/02\/failure-in-assisted-reproduction-treatment-768x432.jpg 768w, https:\/\/fertilityclinicspain.com\/wp-content\/uploads\/2023\/02\/failure-in-assisted-reproduction-treatment.jpg 1179w\" alt=\"failure in assisted reproduction treatment\" width=\"1024\" height=\"576\" \/><\/p>\n<p>So\u2026 don\u2019t think twice! Come talk to us if you think you might have an issue that needs to be addressed!<strong>\u00a0At URE Centro Gutenberg we\u2019ll study your case and will recommend the best options so that\u00a0you can fulfill your desire to become a parent.<\/strong>\u00a0Remember that\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/request-your-appointment\/\" target=\"_blank\" rel=\"noopener\">your first consultation with us is completely cost\u2011free<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>You can\u00a0<a href=\"https:\/\/urecentrogutenberg.es\/en\/your-first-appointment\/\" target=\"_blank\" rel=\"noopener\">request an appointment with URE Centro Gutenberg online<\/a>, or by calling us on\u00a00034\u00a0952\u00a0122\u00a0565.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Human reproduction is a very complex process: it involves several stages, all of which need to go as planned, but that sometimes don\u2019t turn out as we had hoped. An example? A couple undergoing assisted reproduction treatment, specifically\u00a0in Vitro Fertilisation, transfers very good quality embryos to an endometrium which appears to be normal, but they [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":37519,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[499,497],"tags":[511,512,504,529,604,507,508,520,513,603,509,510],"class_list":["post-39523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assisted-reproduction-treatments-and-techniques","category-fertility-problems","tag-assisted-reproduction-clinic-in-algeciras","tag-assisted-reproduction-clinic-in-malaga","tag-assisted-reproduction-techniques","tag-causes-of-infertility","tag-failure-of-implementation","tag-fertility-clinic-in-algeciras","tag-fertility-clinic-in-malaga","tag-fertility-treatments-in-algeciras","tag-fertility-treatments-in-malaga","tag-implant-failure","tag-ivf-clinic-in-algeciras","tag-ivf-clinic-in-malaga"],"_links":{"self":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/comments?post=39523"}],"version-history":[{"count":3,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39523\/revisions"}],"predecessor-version":[{"id":40196,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/posts\/39523\/revisions\/40196"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/media\/37519"}],"wp:attachment":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/media?parent=39523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/categories?post=39523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/tags?post=39523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}