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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Why Us” _builder_version=”4.16″ custom_margin=”||||false|false” custom_padding=”2vw||2vw||true|false” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.27.5″ width=”100%” max_width=”100%” custom_margin=”0px||0px||true|false” custom_margin_tablet=”||0px|” custom_margin_phone=”||||false|true” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|false” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ background_enable_color=”off” custom_padding=”0vw|1vw|4vw|12vw|false|false” custom_padding_tablet=”|4vw||4vw|false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}” padding_tablet=”0px|50px|50px|50px” padding_last_edited=”on|desktop” custom_padding__hover=”|||” padding_phone=”0px|50px|50px|50px”][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”100%” custom_margin=”|||” custom_margin_tablet=”0px|50px||50px” custom_margin_phone=”|||36px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”|||” header_2_font_size_tablet=”” header_2_font_size_phone=”28px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
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Conventional sperm selection<\/strong> techniques used in assisted reproduction (swim-up and density gradients) are based on the recovery or selection of sperm with the best motility and morphology.<\/p>\n In some cases, spermatozoa with normal morphology or motility may exhibit high levels of oxidative stress and DNA fragmentation<\/strong>, two parameters that are not detected in a conventional semen analysis. These abnormalities are significantly more common in subfertile men with abnormal semen parameters, although they can also be found in men with normal semen parameters.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”http:\/\/urecentrogutenberg.es\/wp-content\/uploads\/2020\/06\/macs.jpg” alt=”MACS – URE Centro Gutenberg” title_text=”MACS – URE Centro Gutenberg” force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ custom_margin=”|||” custom_padding=”|||” animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%” border_radii=”off|0.4vw|0vw|0vw|16vw” border_color_all=”rgba(160,208,211,0.35)” border_width_bottom=”1.6vw” border_color_bottom=”#7ec4d5″ border_color_left=”rgba(77,185,211,0.6)” border_radii_last_edited=”off|desktop” border_width_all_tablet=”” border_width_all_phone=”” border_width_all_last_edited=”on|phone” box_shadow_style=”preset3″ box_shadow_vertical=”30px” box_shadow_blur=”80px” box_shadow_spread=”-30px” box_shadow_color=”rgba(102,141,186,0.7)” global_colors_info=”{}” border_radii__hover_enabled=”off|desktop”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” custom_padding_last_edited=”on|phone” _builder_version=”4.27.5″ width=”93%” max_width=”1600px” module_alignment=”left” custom_padding=”||0px|148px|false|false” custom_padding_tablet=”||0px|148px|false|false” custom_padding_phone=”|||40px|false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.5″ global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Oxidative stress:” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#4db9d3″ icon_placement=”left” image_icon_width=”22px” _builder_version=”4.27.5″ header_font=”Montserrat||||||||” header_line_height=”2em” body_font=”Montserrat|300|||||||” body_font_size=”15px” body_line_height=”2em” image_icon_custom_padding=”8px|8px|8px|8px|false|false” custom_padding=”||||false|false” custom_padding_tablet=”||||false|false” custom_padding_phone=”||||false|false” custom_padding_last_edited=”on|phone” animation_style=”fade” animation=”off” border_radii_image=”on|100%|100%|100%|100%” icon_font_size=”22px” use_circle=”on” circle_color=”#4db9d3″ global_colors_info=”{}” image_icon_background_color__sticky_enabled=”#2ea3f2″ image_icon_background_color__sticky=”#2ea3f2″]<\/p>\n This situation arises when there is an imbalance between reactive oxygen species (ROS)<\/strong> and the antioxidant system. ROS are oxidising agents produced during normal cellular metabolism.<\/p>\n [\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”DNA fragmentation:” use_icon=”on” font_icon=”$||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#4db9d3″ icon_placement=”left” image_icon_width=”22px” _builder_version=”4.27.5″ header_font=”Montserrat||||||||” header_line_height=”2em” body_font=”Montserrat|300|||||||” body_font_size=”15px” body_line_height=”2em” image_icon_custom_padding=”8px|8px|8px|8px|false|false” animation_style=”fade” animation=”off” border_radii_image=”on|100%|100%|100%|100%” icon_font_size=”22px” use_circle=”on” circle_color=”#4db9d3″ locked=”off” global_colors_info=”{}” image_icon_background_color__sticky_enabled=”#2ea3f2″ image_icon_background_color__sticky=”#2ea3f2″]<\/p>\n It involves breaks in the DNA strand within the sperm nucleus.<\/p>\n [\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.5″ _module_preset=”default” background_color=”#FFFFFF” width=”100%” max_width=”100%” module_alignment=”center” custom_margin=”||||true” custom_margin_tablet=”||0px|” custom_margin_phone=”||||false|true” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”||||false|false” custom_margin_tablet=”||||false|false” custom_margin_phone=”||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”80px||56px|214px|false|false” custom_padding_tablet=”80px||56px|214px|false|false” custom_padding_phone=”|36px||56px|false|false” custom_padding_last_edited=”on|phone” header_2_font_size_tablet=”40px” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n High levels of oxidative stress can lead to a high rate of DNA fragmentation<\/strong>, which can cause male infertility and compromise the chances of achieving a natural pregnancy, as the genetic integrity of the sperm is essential for embryonic development.<\/p>\n There are different types of sperm DNA fragmentation<\/strong>: single-strand<\/strong> and double-strand<\/strong>. Single-strand breaks are associated with a lower conception rate. On the other hand, double-strand breaks do not prevent pregnancy, but may carry a higher risk of miscarriage.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Services” _builder_version=”4.27.5″ background_color=”#edf6f8″ custom_padding=”3vw|0px|3vw|0px|true|false” border_radii=”|15vw|||” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.5″ background_color=”RGBA(255,255,255,0)” width=”100%” max_width=”100%” module_alignment=”center” custom_margin=”0px||0px||true|false” custom_margin_tablet=”||0px|” custom_margin_phone=”||||false|true” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|false” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ background_enable_color=”off” custom_padding=”0vw|1vw|4vw|12vw|false|false” custom_padding_tablet=”|4vw||4vw|false|false” 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text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”||0px||false|false” custom_margin_tablet=”||0px||false|false” custom_margin_phone=”|||36px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”||0px|0px|false|false” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n There are now more sophisticated methods designed to select sperm in the most physiologically appropriate way possible, ensuring better morphological and motility characteristics and causing less DNA damage.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.5″ width=”100%” max_width=”100%” module_alignment=”center” custom_padding=”0px||0px||true|false” 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header_3_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_blurb title=”Patients with an elevated sperm DNA fragmentation index” use_icon=”on” font_icon=”N||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#4db9d3″ icon_placement=”left” image_icon_width=”13px” content_max_width=”78%” _builder_version=”4.27.5″ header_font=”Montserrat||||||||” header_text_color=”#5b5b5f” header_font_size=”16px” header_line_height=”1.7em” body_font=”Montserrat|300|||||||” body_font_size=”15px” body_line_height=”2em” image_icon_custom_padding=”8px|8px|8px|8px|false|false” width=”100%” custom_margin=”||16px||false|false” animation_style=”fade” animation=”off” border_radii_image=”on|100%|100%|100%|100%” icon_font_size=”13px” use_circle=”on” circle_color=”#4db9d3″ locked=”off” global_colors_info=”{}” image_icon_background_color__sticky_enabled=”#2ea3f2″ image_icon_background_color__sticky=”#2ea3f2″][\/et_pb_blurb][et_pb_blurb title=”Patients with recurrent miscarriage” use_icon=”on” font_icon=”N||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#4db9d3″ icon_placement=”left” image_icon_width=”13px” content_max_width=”78%” _builder_version=”4.16″ header_font=”Montserrat||||||||” header_text_color=”#5b5b5f” header_font_size=”16px” header_line_height=”1.7em” body_font=”Montserrat|300|||||||” body_font_size=”15px” body_line_height=”2em” image_icon_custom_padding=”8px|8px|8px|8px|false|false” width=”100%” custom_margin=”||16px||false|false” animation_style=”fade” animation=”off” border_radii_image=”on|100%|100%|100%|100%” icon_font_size=”13px” use_circle=”on” circle_color=”#4db9d3″ locked=”off” global_colors_info=”{}” image_icon_background_color__sticky_enabled=”#2ea3f2″ image_icon_background_color__sticky=”#2ea3f2″][\/et_pb_blurb][et_pb_blurb title=”Patients who have not achieved a pregnancy after two or more cycles” use_icon=”on” font_icon=”N||divi||400″ icon_color=”#ffffff” image_icon_background_color=”#4db9d3″ 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text_font=”Montserrat|300|||||||” text_text_color=”#289CB9″ text_line_height=”1.8em” header_font=”||||||||” header_text_color=”#5B5B5F” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” header_3_text_color=”#5B5B5F” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”||||false|false” custom_margin_tablet=”||||false|false” custom_margin_phone=”||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”88px|||214px|false|false” custom_padding_tablet=”88px|||214px|false|false” custom_padding_phone=”|16px||32px|false|false” custom_padding_last_edited=”on|phone” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.5″ _module_preset=”default” custom_margin=”0px||0px||false|false” custom_padding=”||0px||false|false” locked=”off” global_colors_info=”{}”][et_pb_row custom_padding_last_edited=”on|phone” _builder_version=”4.27.5″ _module_preset=”default” width=”100%” max_width=”100%” custom_margin=”0px||0px||false|false” custom_padding=”0px|68px|0px|68px|false|false” custom_padding_tablet=”0px|68px|0px|68px|false|false” custom_padding_phone=”|36px||36px|false|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.5″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.5″ _module_preset=”default” width=”90%” custom_padding=”|||156px|false|false” custom_padding_tablet=”|||156px|false|false” custom_padding_phone=”|||0px|false|false” custom_padding_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” admin_label=”Services” _builder_version=”4.27.5″ background_color=”#FFFFFF” custom_padding=”0px|0px|0px|0px|true|false” custom_padding_tablet=”5vw|0px|5vw|0px|true|false” custom_padding_phone=”10vw||10vw||true|false” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.27.5″ width=”100%” max_width=”100%” custom_margin=”68px||68px||true|false” custom_margin_tablet=”||0px|” custom_margin_phone=”||||false|true” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|false” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_enable_color=”off” custom_padding=”4vw|1vw|4vw|12vw|false|false” custom_padding_tablet=”|4vw||4vw|false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}” padding_tablet=”0px|50px|50px|50px” padding_last_edited=”on|desktop” custom_padding__hover=”|||” padding_phone=”0px|50px|50px|50px”][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”100%” custom_margin=”-68px||||false|false” custom_margin_tablet=”0px|50px||50px” custom_margin_phone=”-80px|||24px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||||false|false” custom_padding_tablet=”0px||||false|false” custom_padding_phone=”0px||||false|false” custom_padding_last_edited=”on|phone” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”2em” link_font=”||||||||” ul_font=”||||||||” ol_font=”||||||||” quote_font=”||||||||” header_font=”||||||||” header_2_font=”Montserrat|300|||||||” header_2_text_color=”#212d3b” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”100%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” custom_margin=”|||” custom_margin_tablet=”0px|50px||50px” custom_margin_phone=”|36px||28px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”|||” global_colors_info=”{}”]<\/p>\n Magnetic Activated Cell Sorting<\/em> (MACS),<\/strong> also known as the annexin V column<\/strong>, is a technique used to remove spermatozoa showing signs of apoptosis<\/strong> (programmed cell death), which is generally associated with high oxidative stress leading to DNA fragmentation.<\/p>\n In patients with a high rate of sperm DNA fragmentation, it has been observed that a significant proportion of spermatozoa exhibit cellular damage related to apoptotic processes. In these cases, MACS<\/strong> acts as a complementary technique in semen preparation, with the aim of recovering spermatozoa without markers of apoptosis and selecting those with the highest viability and fertilisation potential for use in assisted reproduction procedures.<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”http:\/\/urecentrogutenberg.es\/wp-content\/uploads\/2020\/06\/fertile-chip-ure-centro-gutenberg.jpg” alt=”ZyM\u00f6t ICSI | URE Centro Gutenberg” title_text=”ZyM\u00f6t ICSI | URE Centro Gutenberg” force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.27.5″ custom_margin=”8px||||false|false” custom_padding=”|||” animation_style=”slide” animation_direction=”right” animation_intensity_slide=”5%” border_radii=”off|0.4vw|0vw|0vw|16vw” border_color_all=”rgba(160,208,211,0.35)” border_width_bottom=”1.6vw” border_color_bottom=”#7ec4d5″ border_color_left=”rgba(77,185,211,0.6)” border_radii_last_edited=”off|desktop” border_width_all_tablet=”” border_width_all_phone=”” border_width_all_last_edited=”on|phone” box_shadow_style=”preset3″ box_shadow_vertical=”30px” box_shadow_blur=”80px” box_shadow_spread=”-30px” box_shadow_color=”rgba(102,141,186,0.7)” global_colors_info=”{}” border_radii__hover_enabled=”off|desktop”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row make_equal=”on” _builder_version=”4.27.5″ width=”100%” max_width=”100%” custom_margin=”||||true” custom_margin_tablet=”||0px|” custom_margin_phone=”||||false|true” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|false” use_custom_width=”on” width_unit=”off” custom_width_percent=”100%” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ background_enable_color=”off” custom_padding=”4vw|1vw|4vw|12vw|false|false” custom_padding_tablet=”|4vw||4vw|false|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}” padding_tablet=”0px|50px|50px|50px” padding_last_edited=”on|desktop” custom_padding__hover=”|||” padding_phone=”0px|50px|50px|50px”][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”100%” custom_margin=”-68px||||false|false” custom_margin_tablet=”0px|50px||50px” custom_margin_phone=”24px|||24px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||||false|false” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”2em” link_font=”||||||||” ul_font=”||||||||” ol_font=”||||||||” quote_font=”||||||||” header_font=”||||||||” header_2_font=”Montserrat|300|||||||” header_2_text_color=”#212d3b” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” custom_margin=”|||” custom_margin_tablet=”0px|50px||50px” custom_margin_phone=”|36px||28px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”|||” global_colors_info=”{}”]<\/p>\n Sperm selection systems based on microfluidics or microchannel flow<\/strong>, such as Zymot Multi, aim to recover spermatozoa with greater motility, better morphology and lower DNA fragmentation, using a process that is more physiologically similar to natural processes than conventional semen preparation methods.<\/p>\n In these state-of-the-art devices, sperm must pass through microchannels or micropores, allowing those with the best motility to be selected and those of lower quality to be discarded. The aim is to exclude sperm with high levels of double-strand DNA fragmentation, increased production of reactive oxygen species (ROS), low motility or abnormal morphology.<\/p>\n However, these systems have limitations in samples with very low sperm concentrations or severely reduced motility, as their operation depends on the sperm\u2019s ability to actively move through the microchannels.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”4.27.5″ background_color=”#FFFFFF” width=”100%” max_width=”100%” module_alignment=”center” custom_margin=”||||true” custom_margin_tablet=”||0px|” custom_margin_phone=”||||false|true” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|false” disabled=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”36px||||false|false” custom_padding=”|||214px|false|false” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”||52px||false|false” custom_padding=”|||214px|false|false” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n Sperm selection using MACS<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”||||false|false” custom_padding=”|||214px|false|false” header_2_font_size_tablet=”40px” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n Magnetic Activated Cell Sorting<\/em> (MACS),<\/strong> also known as the annexin V column<\/strong>, is a technique used to remove spermatozoa showing signs of apoptosis<\/strong> (programmed cell death), which is generally associated with high oxidative stress leading to DNA fragmentation.<\/p>\n In patients with a high rate of sperm DNA fragmentation, it has been observed that a significant proportion of spermatozoa exhibit cellular damage related to apoptotic processes. In these cases, MACS<\/strong> acts as a complementary technique in semen preparation, with the aim of recovering spermatozoa without markers of apoptosis and selecting those with the highest viability and fertilisation potential for use in assisted reproduction procedures.<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”||||false|false” custom_padding=”|||214px|false|false” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.27.5″ text_font=”Montserrat|300|||||||” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”|300|||||||” header_2_font_size=”40px” header_2_line_height=”1.5em” max_width=”90%” max_width_tablet=”100%” max_width_phone=”” max_width_last_edited=”on|tablet” module_alignment=”left” custom_margin=”||||false|false” custom_padding=”||56px|214px|false|false” header_2_font_size_tablet=”40px” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n Sperm selection systems based on microfluidics or microchannel flow<\/strong>, such as Zymot Multi, aim to recover spermatozoa with greater motility, better morphology and lower DNA fragmentation, using a process that is more physiologically similar to natural processes than conventional semen preparation methods.<\/p>\n In these state-of-the-art devices, sperm must pass through microchannels or micropores, allowing those with the best motility to be selected and those of lower quality to be discarded. The aim is to exclude sperm with high levels of double-strand DNA fragmentation, increased production of reactive oxygen species (ROS), low motility or abnormal morphology.<\/p>\n However, these systems have limitations in samples with very low sperm concentrations or severely reduced motility, as their operation depends on the sperm\u2019s ability to actively move through the microchannels.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer” _builder_version=”4.16″ background_color=”#289cb9″ custom_padding=”3vw|0px|3vw|0px|true|false” top_divider_height=”660px” top_divider_flip=”horizontal” bottom_divider_style=”clouds2″ bottom_divider_color=”rgba(255,255,255,0.08)” bottom_divider_height=”600px” bottom_divider_flip=”vertical” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”http:\/\/urecentrogutenberg.es\/wp-content\/uploads\/2020\/05\/health-icon-10-2.png” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ text_font=”Montserrat||||||||” header_font=”||||||||” header_2_font=”Montserrat|300|||||||” header_2_text_align=”center” header_2_font_size=”50px” header_2_line_height=”1.4em” text_orientation=”center” background_layout=”dark” header_2_font_size_tablet=”” header_2_font_size_phone=”30px” header_2_font_size_last_edited=”on|phone” header_2_line_height_tablet=”1.4em” header_2_line_height_phone=”” header_2_line_height_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n Please fill in the form or call us on (+34) 952 122 565.<\/p>\n [\/et_pb_text][wpforms_selector form_id=”35710″ module_class=”pedircitaform” _builder_version=”4.13.0″ _module_preset=”default” global_colors_info=”{}”][\/wpforms_selector][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Advanced sperm selection techniquesCharacteristics of conventional techniquesConventional sperm selection techniques used in assisted reproduction (swim-up and density gradients) are based on the recovery or selection of sperm with the best motility and morphology. In some cases, spermatozoa with normal morphology or motility may exhibit high levels of oxidative stress and DNA fragmentation, two parameters that […]<\/p>\n","protected":false},"author":16,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-41128","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/pages\/41128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/comments?post=41128"}],"version-history":[{"count":9,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/pages\/41128\/revisions"}],"predecessor-version":[{"id":41208,"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/pages\/41128\/revisions\/41208"}],"wp:attachment":[{"href":"https:\/\/urecentrogutenberg.es\/en\/wp-json\/wp\/v2\/media?parent=41128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What are the latest techniques like?<\/h2>\n
These sperm selection techniques are recommended in the following cases:<\/strong><\/h3>\n
\n
Our medical and biological team will advise you and recommend the use of these techniques in cases where it is deemed appropriate, following an individual assessment of each patient.<\/h3>\n<\/blockquote>\n
Some of the techniques we use at URE Centro Gutenberg are:<\/strong><\/h3>\n
Sperm selection using MACS<\/strong><\/h4>\n
Sperm selection using microfluidics or microchannels.<\/strong><\/h4>\n
Some of the techniques we use at URE Centro Gutenberg are:<\/strong><\/h3>\n
Sperm selection using microfluidics or microchannels.<\/strong><\/h4>\n
Further information<\/h2>\n