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What is the Sperm FISH Analysis?

The Sperm FISH Analysis is a technique which allows us to study the number of chromosomes that the sperm in a semen sample have. With this technique we can determine whether or not the sperm have a normal chromosomal makeup (23 chromosomes), or if they have an abnormal chromosomal makeup (abnormal sperm FISH).

An abnormal sperm FISH analysis signifies an increase in chromosome anomalies in the male’s sperm. This means that the chances of having an embryo with chromosomal alterations could be greater, and these alterations could be responsible for recurring miscarriages and/or implantation failure. In couples with an abnormal sperm FISH analysis, it is recommended that the embryos that they have had fertilised via In Vitro Fertilisation undergo a Preimplantation Genetic Diagnosis before transfer to the female’s uterus.

When is a Sperm FISH Analysis Recommended?

  • When there is some type of severe abnormality in the semen such as a low sperm count (oligozoospermia).
  • In patients who have had repeated miscarriages due to unknown causes.
  • In patients who have had previous unsuccessful attempts at In Vitro Fertilisation.

The Sperm FISH Analysis Procedure

The only thing that is necessary for the analysis is that the male provide a semen sample to our laboratory for initial evaluation (sperm motility and sperm count). Afterwards, the sample will be sent to a Genetics Reference Laboratory. The test results will be ready in approximately three weeks.